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[11] [4] The medication may reduce the effectiveness of oral contraceptives, requiring alternative contraception during initiation and dose escalations

Some require immediate attention: Severe, persistent abdominal pain (could be pancreatitis) Signs of dehydration (dark urine, extreme dizziness, cant keep fluids down) Vision changes Severe allergic reactions (throat swelling, difficulty breathing) Continuous vomiting that prevents eating or taking medication Upper right abdominal pain with yellowing skin (gallbladder issues) Dehydration from GI side effects can cause kidney problems

Sitagliptin and risk of fractures in type 2 diabetes: results from the TECOS Trial

Insulin, produced by the pancreas, allows cells to absorb glucose from the bloodstream for energy or storage

Its clinical trial (STEP 1) showed an average weight loss of 14.9% and up to 20.7% with the newly approved 7.2mg dose (STEP UP, Lancet 2025)